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management neurology anesthesia anesthesiology intraoperative workup 21hydroxylasedeficiency 21ohd anaphylaxis bullous comatose dermatology differential embolism embolus encephalopathy genetics gravis hyperthermia malignant
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Malignant Hyperthermia Crisis - Guidelines for Crises in Anaesthesia Unexplained increase in ETCO2 AND tachycardia AND increased
Guidelines for Crises ... rise is a late sign ... other, more common causes ... (see 2-8 Peri-operative ... Guidelines for crises
Intraoperative Circulatory Embolus - Guidelines for Crises in Anaesthesia Causes: thrombus, fat, amniotic fluid, air/gas. Signs: hypotension, tachycardia,
Guidelines for Crises ... in Anaesthesia Causes ... Signs: hypotension ... then 90 mg over 2 ... Guidelines for crises
Bullous Pemphigoid - Diagnosis and Management Summary Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Bullous Pemphigoid - Diagnosis ... Management Summary Pathophysiology ... dermis Clinical Signs ... - Erosions and crusts ... topical steroids 2.
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia • Unexplained hypotension • Unexplained bronchospasm (wheeze may be absent
Guidelines for Crises ... of more of the signs ... repeat sample at 1-2 ... Guidelines for crises ... #Diagnosis #Management
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Ptosis, diplopia 2. ... muscles: “myasthenic crises ... - Peek sign ... 2. ... Myasthenia Crises
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
• Hypertensive crisis ... Etiology: • Pathophysiology ... the underlying cause ... Seizures: Treat with AEDs ... until cause identified
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
Differential Diagnosis ... • Mutism Pathophysiology ... safe to stop 2. ... • Examine for signs ... Casey Albin MD @
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... develops later 2. ... • Bilateral signs ... - More than 2/ ... • Infectious causes
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
kidney injury 2) ... anemia (MAHA) Pathophysiology ... Biopsy to confirm diagnosis ... , add other BP meds ... • Refractory cases
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