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diagnosis differential ana antinuclear classification diseases vasculitis anca antineutrophil associations autoantibodies bloodsmear borrelia clinical cryoglobulinemia cryoglobulins management pathology patterns prs
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... Microscopic polyangiitis ... Goodpasture's syndrome ... #antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... cases • Sjögren syndrome ... Vasculitis: • Microscopic ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
or Anti-NucIear Antibody ... Using fluorescence microscopy ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal Syndromes ... polyangiitis), MPA (microscopic ... Pulmonary Renal Syndromes ... EGPA) • Auto-antibodies ... Pulmonary #Renal #Syndromes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... cryoglobulinemia syndrome ... Cryoglobulinemia Syndrome ... 20% Sjögren's syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
PR3-ANCA): • Microscopic ... Mucocutaneous lymph node syndrome ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... C-ANCA) pattern: antibodies
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
resolved after 2-3d ... Syndrome: 3d of ... and convalescent antibodies ... recurrentis #BloodSmear #microscopy
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