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agglutinin anemia approach arthritis cold degenerative disease hematology inflammatory joint jointdisease jointpain pain pathophysiology versus workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Mycoplasma, EBV, HIV ... younger pts) Differential ... test #cold # ... #anemia #hematology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
nociceptors -> Pain with rest ... knee hip and L/ ... #Degenerative #Comparison ... #Versus #MSK #JointDisease ... #JointPain #Diagnosis
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
e.g., congenital hip ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential ... #diagnosis #arthritis
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