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diagnosis clinical differential neurology algorithm endocrinology adrenal causes msk insufficiency radiology signs symptoms management orthopedics pocus nephrology pathophysiology physicalexam ultrasound
ACTH LH Cholesterol cholesterol desmolase Pregnenolone 17a-hydroxylase 17 Hydroxyregnenolone 17,20-lyase 3B-hydroxysteroid dehydrogenase 3B-hydroxysteroid dehydrogenase 17a-hydroxylase #Progesterone 17-Hydroxyprogesterone 17,20-lyase 21ß-hydroxylase 21ß-hydroxylase 11-Deoxycorticosterone 11-Deoxycortisol 11ß-hydroxylase 11ß-hydroxylase #Cortisol #Dehydroepiandrosterone #DHEA 3ß-hydroxysteroid dehydrogenase 个 #Androstenedione #17B-hydroxysteroid #dehydrogenase #Testosterone #aromatase #FSH #Estradiol #5a reductase #Corticosterone aldosterone synthase #Aldosterone Angiotensin || #Dihydrotestosterone (DHT)
11ß-hydroxylase #Cortisol ... #Estradiol #5a
Adrenal Insufficiency Algorithm - Cosyntropin Stimulation Test T-1m: Baseline cortisol drawn T0: 250 µg cosyntropin given IV T30m: Repeat
T-1m: Baseline cortisol ... IV T30m: Repeat cortisol ... drawn T60m: Final cortisol
Cushing Syndrome Testing Algorithm INDICATIONS FOR TESTING: • Suspected Cushing syndrome (central obesity, muscle weakness, refractory hypertension) Testing:
hypertension) Testing: • Cortisol ... Free Urine • Cortisol ... following morning: Cortisol ... , Serum (or Cortisol
Evaluation of Secondary Hypertension • Primary aldosteronism - PRA, PAC • Renal artery stenosis - Renal
Late-night salivary cortisol ... 24-h urine free cortisol
Adrenal Insufficiency Diagnosis Algorithm - Evaluation of HPA Axis Response to ACTH Early am cortisol < 3
ACTH Early am cortisol ... Cosyntropin - Measure cortisol ... injection - If f/u cortisol
Diagnosis Adrenal Insufficiency - Algorithm Step 1) Screening Test: 6-8AM Cortisol Level - Early morning cortisol levels
Screening Test: 6-8AM Cortisol ... Early morning cortisol ... Then, check cortisol ... - Peak cortisol
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
glands with lack of cortisol ... RTA type IV) Cortisol ... • Myalgia Cortisol ... BP • ↓ Serum cortisol ... potassium, AM cortisol
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
A baseline 8am cortisol ... diagnostic of AI and a cortisol ... Obtain baseline cortisol ... Measure cortisol ... and 60 minutes Cortisol
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
higher circulating cortisol ... 24-hour urine cortisol ... morning serum cortisol ... midnight salivary cortisol ... midnight serum cortisol
Principal features of Destructive and Irritative cortical lesions in right-handed individual #Cortical #Cortex #Lesions #Features #Signs #Symptoms
and Irritative cortical ... individual #Cortical
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