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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... tract: abdominal pain ... • Cogan Syndrome ... Presentation - Systemic Symptoms ... , testes -> pain
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... tract: Abdominal pain ... • Progressive symptoms ... tract, and often causes ... • Cogan syndrome
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... palpable purpura 2/2 vasculitis ... or serologies + symptoms ... Goodpasture's cause ... diagnosis #management #treatment
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Inflammation and pain ... Causes: - Idiopathic ... Leukocytoclastic vasculitis ... Treatment: - Systemic ... #dermatology #oncology
Cauda Equina Syndrome Overview

Cauda Equina Syndrome:
 • Prevalence: 1:33,000-100,000 ppl/yr
 • Incidence: 1.5-3.4 million ppl/yr
 •
spine L1-L5 Symptoms ... so-called ‘red flag’ symptoms ... dysfunction SPINE Mnemonic ... - Emergency Causes ... axial T1 and T2 Treatment
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
wasting, radicular pain ... dysfunction, back pain ... Reconstitution Inflammatory Syndrome ... Meningitis • Include: vasculitis ... • Caused by immune
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... Diagnosis: >3 symptoms ... management #hematology #oncology
Bronchiectasis - Summary

What?
• Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
Chronic inflammation causes ... inflammation Symptoms ... weight • Chest pain ... • Mounier-Kuhn syndrome ... mycobacteria Treatment
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
starting amiodarone treatment ... respiratory distress syndrome ... gradually with symptoms ... Pleuritic chest pain ... Improvement in symptoms