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Treatment Approach to Hodgkin's Lymphoma

By Matthew Ho, MD PhD @MatthewHoMD
With Credit: Dr Sunita Nasta and Dr
Treatment Approach ... to Hodgkin's Lymphoma ... guidelines #Hodgkins ... #Lymphoma #oncology ... #Hematology #management
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Hodgkin's Lymphoma ... Hodgkin's Lymphoma ... , Hodgkin Lymphomas ... #comparison #oncology ... #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's Lymphoma ... accounts for 10% of all ... Lymphoma Treatment ... #lymphoma #diagnosis ... #oncology #management
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
- Differential Diagnosis ... Biopsy • Hodgkin's ... Lymphoma #Diffuse ... #Differential #Diagnosis ... #Oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... Depletion Non-Hodgkin ... Responsive to Treatment ... #Diagnosis #NonHodgkin
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... microglobulin Treatment ... PML leukemia, Hodgkin ... #workup #oncology ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Rebound effect from treatment ... Metastatic cancer, Lymphoma ... Inflammatory Conditions: Rheumatologic ... • Reaction to Medications
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
and secondary lymphoid ... Small lymphocytic lymphoma ... of large cell lymphoma ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemopathies+++: Hodgkin ... , T-cell lymphoma ... , B-cell lymphoma ... #management #treatment ... #summary #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
minimal tumor burden Diagnosis ... to large cell lymphoma ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management