10 results
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
at anytime if toxicity ... Theophylline - For i/v infusion ... - Continuous infusion ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Local Anaesthetic Toxicity - Guidelines for Crises in Anaesthesia
Signs of severe toxicity:
 • Sudden alteration in
Local Anaesthetic Toxicity ... Signs of severe toxicity ... tachyarrhythmias may all ... anaesthetic (remember infusion ... Diagnosis #Management #Workup
The crusade against “Ab”Normal Saline continues.  This is a non-physiologic fluid that can harm our
ECF and ICF both work ... blood flow and perfusion ... Balanced crystalloids ... diagnosis #treatment #pharmacology ... #physiology #crystalloids
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Propofol-Related Infusion ... Propofol #Related #Infusion ... Diagnosis #Management #Pharmacology ... #Toxicity #Toxicology
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
pack. ❸ Remove all ... an adrenaline infusion ... noradrenaline infusion ... Give rapid i.v. crystalloid ... Diagnosis #Management #Workup
Intraoperative  Bradycardia - Guidelines for Crises in Anaesthesia
Bradycardia in theatre should not be treated as
reservoir bag and APL ... rate, rhythm, perfusion ... local anaesthetic toxicity ... Diagnosis #Management #Workup
Intraoperative Tachycardia - Guidelines for Crises in Anaesthesia
Tachycardia in theatre is often due to inadequate depth
reservoir bag and APL ... rate, rhythm, perfusion ... local anaesthetic toxicity ... Diagnosis #Management #Workup
Hypotension - Guidelines for Crises in Anaesthesia

Hypotension is commonly due to unnecessarily deep anaesthesia, the autonomic
reservoir bag and APL ... rate, rhythm, perfusion ... Local anaesthetic toxicity ... Diagnosis #Management #Workup
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... be effective in all ... evidence of marrow toxicity ... #Toxicity #Management ... #Pharmacology
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity
Anthracyclines cause cardiomyopathy:
 ✖ Reduction in left ventricular ejection fraction
after 4 cycles for all ... dose, continuous infusion ... cardiology #oncology #pharmacology ... #toxicity #chemotherapy