11 results
Eosinophilic Pneumonia
When to suspect Eosinophilic Pneumonia? Non-resolving pneumonia + BAL > 25% eosinophils + excluded more
Eosinophilic Pneumonia ... When to suspect Eosinophilic ... Eosinophilia - ... tobacco hx, >60% asthma ... Eosinophilia (~
Biologic therapy for eosinophilic asthma 
• Mepolizumab (Nucala) 
  • Anti-lL-5, 100 mg SQ q4
asthma • Mepolizumab ... eosinophils >150 ... eosinophils >400 ... eosinophils >300 ... eosinophils >150
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... Bugs: - Fungus (aspergillosis ... DRESS - AIN - Eosinophilic ... Dermatitis - Asthma ... coyefish379 #Eosinophilia
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... Diseases • Acute Eosinophilic ... SOB • Chronic Eosinophilic ... Bronchopulmonary Aspergillosis ... fever, rhinitis • Eosinophilic
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... FOR TESTING: • Peripheral ... blood eosinophilia ... specific symptoms • Eosinophilia ... common causes are asthma
First-line therapies for Asthma, Asthma-COPD Overlap and COPD

The diagnosis of COPD, asthma, and ACO initially requires
therapies for Asthma ... , Asthma-COPD Overlap ... , and ACO initially ... analysis with eosinophil ... ACO = asthma-COPD
On the left we see a chest film with a typical finger-in-glove shadow.
The HRCT shows focal
clinical setting (asthma ... and serum eosinophilia ... bronchopulmonary aspergillosis ... ABPA #Allergic #Aspergillosis
Allergic Bronchopulmonary Aspergillosis (ABPA)
WHAT IS IT?
Hypersensitivity response to Aspergillus fumigatus in the airways
 • Primarily affects
Bronchopulmonary Aspergillosis ... with underlying asthma ... Aspergillus • Peripheral ... eosinophilia and ... Bronchopulmonary #Aspergillosis
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
Inflammatory mechanism of asthma ... draining lymph nodes, where ... subepithelial mucosa, where ... chemokine for eosinophils ... #asthma #pathophysiology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), EGPA (eosinophilic ... hemorrhage (DAH), asthma ... pulmonary nodules, asthma ... differential (check eosinophil ... sparing of the lung periphery