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Diagnosis Adrenal Insufficiency - Algorithm Step 1) Screening Test: 6-8AM Cortisol Level - Early morning cortisol levels
specificity for AI ... > 15 excludes AI ... have diagnosed AI ... Step 3) Differentiate ... primary vs secondary AI
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm ACTH-Dependent (Secondary): • Pituitary Dysfunction • Hypothalamic Dysfunction ACTH-Independent (Primary):
Insufficiency - Differential ... Diagnosis Algorithm ACTH-Dependent ... Hypothalamic Dysfunction ACTH-Independent ... Insufficiency #AI ... #Differential #
Adrenal Insufficiency Diagnosis Algorithm - Evaluation of HPA Axis Response to ACTH Early am cortisol < 3
Axis Response to ACTH ... primary OR secondary AI ... Measure ACTH: ... High = primary AI ... Diagnosis #Algorithm #ACTH
Algorithm for the diagnosis of adrenal insufficiency (AI). The standard cosyntropin stimulation test (CST) may be
insufficiency (AI ... secondary or tertiary AI ... ACTH, adrenocorticotropic ... Diagnosis #Endo #ACTH
Primary vs Secondary Adrenal Insufficiency - Pathophysiology Primary AI = adrenal glands themselves are the problem. This
Pathophysiology Primary AI ... be low, while ACTH ... Secondary AI = the ... Low ACTH leads to
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm Exogenous (ACTH-independent) Endogenous • ACTH-dependent: - ACTH-secreting
) - Simplified Differential ... Endogenous • ACTH-dependent ... : - ACTH-secreting ... Disease) - ACTH-secreting ... Cushings #syndrome #Differential
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
In secondary AI ... is absent (low ACTH ... diagnostic of AI ... ACTH STIM TEST: ... baseline cortisol and ACTH
Adrenal Insufficiency Differential Diagnosis Algorithm Clinical suspicion: Weakness, fatigue, nausea, musculoskeletal pain, dizziness, volume depletion, abdominal pain,
Insufficiency Differential ... Baseline plasma ACTH ... High baseline ACTH ... normal baseline ACTH ... Insufficiency #Differential
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
AM cortisol and ACTH ... /dL -> Primary AI ... present - ACTH ... ug/dL Primary AI ... present - ACTH
Benign Adrenal Mass - Differential Diagnosis Algorithm Hyperplasia - Often Bilateral • Congenital Adrenal Hyperplasia • ACTH
Adrenal Mass - Differential ... Hyperplasia • ACTH ... Dependent • ACTH ... AdrenalMass #Benign #Differential
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