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diagnosis betadglucan cardiology fungal arthritis aspergillus biomarkers comparison falsepositives infections infectiousdiseases intermittent joint laboratory management monoarthritis monoarticular msk oligoarthritis oligoarticular
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... • Typhus, gram-negative ... Non-Infectious Causes ... Brucellosis • Liver or lung ... #Patterns #Differential
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Coccidioides - Negative ... BAL GM does not differentiate ... decreased with: concurrent ... Clav (may be + as long ... post-2010 almost never
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
verrucous) • Lung ... • Coagulase-negative ... night sweats, fever ... Septic Emboli Cause ... Marantic (NTBE) Differential
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Almost always negative ... in BAL does not differentiate ... Sensitivity ↓ w/concurrent ... result in + as long ... post-2010 almost never
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
and Differential ... , verrucous) - Lung ... aureus, Coagulase-negative ... night sweats, fever ... #Differential #
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... • Is there a pattern ... weeks) Can Be Caused ... • Bacterial endocarditis ... aureus • Gram-negative
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