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diagnosis hematology anemia cardiology agglutinin algorithm cold disease elevated infectiousdiseases laboratory lactate ldh management nonpalpable palpable purpura rheumatology testing workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Glucose-6-phosphate dehydrogenase ... mechanical cardiac valve ... bartonella (oroya fever ... #Anemia #Differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate Dehydrogenase ... (LDH) - Differential ... - Prosthetic valves ... myocarditis, rheumatic fever ... #Elevated #differential
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Involves aortic and mitral ... night sweats, fever ... Marantic (NTBE) Differential ... Paradoxical emboli via ASD ... Persistent bacteremia/fevers
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Polyclonal - Viral ... Elevated lactate dehydrogenase ... younger pts) Differential ... Symptoms: High fevers ... #anemia #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... mountain spotted fever ... • Bacterial endocarditis ... #nonpalpable #dermatology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
and Differential ... involves aortic and mitral ... night sweats, fever ... Persistent bacteremia/fevers ... #Endocarditis #Differential
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