20 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... Syndrome: Proximal tubule ... Distal convoluted tubule ... Syndrome: Collecting tubule ... Pathophysiology #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Defects in Kidney Tubule ... distal convoluted tubule ... receptor activity #Tubule ... Defects #Kidney #Nephrology ... #Table
Renal Tubular Acidosis (RTA) Diagnosis and Management
 • Distal (type 1) RTA
 • Proximal (type 2)
Renal Tubular Acidosis ... (RTA) Diagnosis ... 4) RTA #rta #Renal ... #Tubular #Acidosis ... #nephrology #table
Proximal Renal Tubular Acidosis (RTA) Ttype 2 Overview

HCO3 reabsorptive failure
Lowering of threshold for HCO3 absorption in
Proximal Renal Tubular ... absorption in proximal tubule ... Acidosis #Proximal #Diagnosis ... #Management #Nephrology
Renal Tubular Acidosis (RTA) 
Type 1 - Failure of secretion
Type 2 - Bicarbonate wasting
Type 4 -
Renal Tubular Acidosis ... salt diet #Renal ... #Tubular #Acidosis ... #RTA #types #classification ... #nephrology #diagnosis
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... in the distal tubule ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology ... #diagnosis
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
tubular dysfunction ... syndromes - Gitelman ... #Differential #Diagnosis ... Low #Magnesium #Table ... #Classification
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
GI Losses - Gastric
 • Vomiting
 • NG suction
GI
- Differential Diagnosis ... Chloridorrhea Renal ... Losses - Impaired tubular ... Hypomagnesemia • Barrter's/Gitelman's ... MetabolicAlkalosis #NonGap #Nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential Diagnosis ... hypokalemia • Renal ... tubular acidosis ... Bartter's syndrome, Gitelman's ... algorithm #causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... • Hypokalemia (renal ... tubular acidosis ... #Syndrome #diagnosis ... #nephrology #management