17 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... prevalence of 1- ... in the distal tubule ... #Pathophysiology
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
Diagnosis and workup ... 1) Clinical ... the diagnostic workup ... Aphaso-apraxo-agnosia syndrome ... (parkinsonian signs
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Onset Alzheimer's (1% ... - Presenilin 1 ... mutations - Down syndrome ... chromosome 21) Signs ... AlzheimersDisease #Dementia #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... hemianopsia IGF-1 ... Carpal Tunnel Syndrome ... Overproduction #diagnosis #signs ... endocrinology #pathophysiology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... should be done): 1. ... hypertension and signs ... renal bruit or signs ... • Other: 1.
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
anaphylaxis (→ 3-1) ... hyperthermia crisis (late sign ... • Serotonin syndrome ... Anticholinergic syndrome ... Diagnosis #Management #Workup
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... Specific sarcoidosis syndromes ... symptoms) • Löfgren syndrome ... • Heerfordt syndrome ... Diagnosis #Management #Signs
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Female:Male 9:1 ... 65 years PBC Pathophysiology ... failure PBC Signs ... • AMA titer 1: ... cholangitis #diagnosis #workup
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
malignancy Pathophysiology ... Beckwith Wiedemann syndrome ... Diagnosis and Workup ... • Serum IGF-1 ... Endocrinology #Treatment #Pathophysiology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
localized) 1. ... • Acute stroke syndromes ... Lack of UMN/LMN signs ... dystrophies Work ... synthetase [anti-Jo-1]