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diagnosis differential autoimmune aiha causes hemolysis agglutinin classification comparison extravascular intravascular management monoclonal oncology paraproteinemias table treatment
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Warm vs Cold Autoimmune ... Hemolytic Anemia ... Hemolytic Anemia ... #Hemolytic #Anemia ... #hematology #diagnosis
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Diagnosis Table Warm ... Agglutinin Disease ... Diagnosis #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Autoimmune (AIHA) "Warm ... (e.g. primary cold ... differential #diagnosis #hematology ... #anemia
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Anemia (AIHA) Treatment ... Warm AIHA: 1) Steroids ... esp if severe disease ... azathioprine Cold ... Treatment #management #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
or fingers • Acrocyanosis ... anemia • Cold ... Mycoplasma, EBV, HIV ... #hemolytic #anemia ... #hematology #diagnosis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Anemia Intrinsic ... Causes: • Liver disease ... Hypersplenism • AIHA: warm ... , cold, drug induced ... classification #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... - Autoimmune: Warm ... AIHA, Cold AIHA ... Defects: Sickle cell anemia ... Differential #Diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... • Heavy Chain disease ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology
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