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Primary hypoadrenalism (Addison’s disease) – symptoms, signs

#Diagnosis #Hypoadrenalism #Addisons #Disease #Hypoadrenalism #Signs #Symptoms

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hypoadrenalism (Addison ... symptoms, signs #Diagnosis ... Hypoadrenalism #Addisons ... Basic and Clinical Endocrinology
Cutaneous signs of Addison's disease may be a useful clue. Hyperpigmentation especially involves sun-exposed areas and
Cutaneous signs of Addison's ... Diagnosis is more ... #Addisons #disease ... Clinical #Cutaneous #Diagnosis
Adrenal Insufficiency Differential Diagnosis Algorithm
Clinical suspicion: Weakness, fatigue, nausea, musculoskeletal pain, dizziness, volume depletion, abdominal pain,
Insufficiency Differential Diagnosis ... insufficiency likely: • High ... baseline ACTH - ... #Differential #Diagnosis ... #Algorithm #endocrinology
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Insufficiency Addison's ... Serum DHEAS Diagnosis ... insufficiency #addisons ... #disease #endocrinology ... #diagnosis #signs
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm
Exogenous (ACTH-independent)
Endogenous
 • ACTH-dependent:
    - ACTH-secreting
Simplified Differential Diagnosis ... Endogenous • ACTH-dependent ... : - ACTH-secreting ... #Differential #Diagnosis ... #Algorithm #endocrinology
Benign Adrenal Mass - Differential Diagnosis Algorithm
Hyperplasia - Often Bilateral
 • Congenital Adrenal Hyperplasia
 • ACTH
- Differential Diagnosis ... Hyperplasia • ACTH ... Dependent • ACTH ... #Differential #Diagnosis ... #Algorithm #Endocrinology
Diagnosis Adrenal Insufficiency - Algorithm

Step 1) Screening Test: 6-8AM Cortisol Level
 - Early morning cortisol levels
Diagnosis Adrenal ... lower, you have diagnosed ... pituitary gland) - High ... Insufficiency #Algorithm #Diagnosis ... #Endocrinology
Adrenal Insufficiency Diagnosis Algorithm - Evaluation of HPA Axis Response to ACTH

Early am cortisol < 3
Insufficiency Diagnosis ... Axis Response to ACTH ... : - High = primary ... #Algorithm #ACTH ... Stimulation #Test #Endocrinology
Suspected Celiac Disease - Diagnosis Algorithm

Celiac disease suspected:
 • Signs and symptoms of celiac disease
 •
Celiac Disease - Diagnosis ... hepatitis, T1DM, Addisons ... • Lymphoma • High ... Celiac #Disease #Diagnosis
Adrenal Insufficiency Diagnosis Algorithm
Test 1: Baseline AM Cortisol 
 - Beware of major normal value
 -
Insufficiency Diagnosis ... Falsely elevated in high ... pregnancy) Test 2: ACTH ... Insufficiency #Diagnosis ... #Algorithm #endocrinology