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Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... and Aggregometry ... count and platelet ... • Platelet flow ... differential #diagnosis #Aggregometry
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis Platelet ... Differential #Diagnosis #causes ... #Platelets #hematology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... • Absence of platelet
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... and Platelet Disorders ... History: - Prior platelet ... practices that could cause ... Thrombocytopenia #Platelet
Causes of Acquired Platelet Dysfunction #Acquired #Platelet #Dysfunction #Causes #differential #Diagnosis #hematology
Causes of Acquired ... Platelet Dysfunction ... #Acquired #Platelet ... #Dysfunction #Causes
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
children) • Platelets ... extremely low platelet
Causes of Thrombocytopenia. Platelet counts may be depressed because of decreased production or due to increased platelet
Causes of Thrombocytopenia ... Platelet counts ... due to increased platelet ... #Differential #Causes
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 Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct 60% Platelet ... concentrate - Platelets ... Hct < .005) Platelet ... pheresis - Platelets
Thromboelastography (TEG) based therapy and Management If r time prolonged -> FFP If MA low -> plts/cryoprecipitate (if
cryoprecipitate If platelets ... < 50 - > platelet
Thromboelastography (TEG) Based Management - If R time prolonged -> FFP - If MA low
cryoprecipitate - If platelets ... < 50 -> platelet
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