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Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Type I Hypersensitivity ... bind to harmless allergens ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Hypersensitivity ... Immunological Target: Allergen ... Ex: Antibiotic allergies ... cephalosporin), Food allergies ... Immunological Target: Allergen
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity ... When the specific allergen ... , and drug allergies ... Type Ill - IgG and ... sclerosis #Hypersensitivity
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
Type IV Hypersensitivity ... mediated; exposure to allergen ... development of allergen-specific ... Initial exposure to allergen ... recognize antigen on allergen's
Exposure Related ILD • Hypersensitivity pneumonitis • Pneumoconioses • Radiation pneumonitis • Medication-induced ILD Andrew Sanchez
Exposure Related ILD ... • Hypersensitivity ... Medication-induced ILD ... Exposure #Related #ILD
Asthma: immunopathogenesis. Allergens attach to, and are taken up by, dendritic cells that he the respiratory
Allergens attach ... interaction of the allergen ... IL-4 activates B ... degranulate when the allergens ... are activated by IL
Causes of Urticaria Immunoglobulin E (IgE) mediated - Aeroallergens - Contact allergen - Food allergens - Insect
Aeroallergens - Contact allergen ... - Food allergens ... mediated - Contact allergen
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 Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
Lung Diseases (ILD ... Exposure-Related ILD ... alveolitis): • Hypersensitivity ... ILD caused by inhalation ... Methotrexate ILD
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
table of types of hypersensitivity ... Mechanism of Action: Allergen-specific ... Hay fever, Food allergies ... , Drug allergies ... Graft rejection #hypersensitivity
ILD of Known Cause - Differential Diagnosis Exposure: • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis • Treatment Related:
ILD of Known Cause ... Asbestosis, Silicosis, Hypersensitivity ... BrighamChiefs #ILD
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