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Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Dermatomyositis Clinical ... Muscle swelling - Fever ... Allopurinol for
Drugs that Cause Fever
Most commonly:
Amphotericin B, Antihistamines, Asparaginase, Barbiturates, Bleomycin sulfate, Methyldopa, Penicillins, Phenytoin sodium, Procainamide,
Drugs that Cause Fever ... Occasionally: Allopurinol ... hydrochloride #Drug #Fever
Faget Sign - Pulse-Temperature Dissociation
Causes of Relative Bradycardia
 • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... (Step ladder: fever ... Intermittent Fever ... or no fever
Faget's Sign & Liebermeister's Rule
Pulse-Temperature Dissociation
EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM
INFECTIOUS
Psittacosis • Q Fever ... • Typhoid Fever ... • Drug Fever ... CLINICAL UTILITY ... Typhoid Fever (S
Allopurinol and its active metabolite inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and
Allopurinol and ... the effects of allopurinol
Causes of Relative Bradycardia - Note the propensity for intracellular organisms.
Infectious: 
Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
Ever had a #traveler come in to your clinic with #fever and you were not sure
Ever had a #traveler ... come in to your clinic ... with #fever and ... infectiousdisease #fever
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Inflammation of Gout Allopurinol
Medications for Prevention of Chronic Gout
Colchicine (Colcrys)
Pegloticase (Krystexxa)
Probenecid
Xanthine oxidase inhibitors:
 - Allopurinol (Zyloprim)
 - Febuxostat (Uloric)
#Chronic
inhibitors: - Allopurinol