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diagnosis deficiency hematology algorithm causes mcv vitamin atlas autoantibodies bloodcell bypass celiac cobalamin copper deficiencies disease erythematosus gastric gastroenterology lupus
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... inflammation) • Iron ... Sideroblastic anemia ... ACD, Aplastic anemia ... MatthewHoMD #Anemia
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
anemia • Vitamin ... B12 - Macrocytic ... anemia, cognitive ... - Anemia • Zinc ... cognitive dysfunction, anemia
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... MCV - <80fL - "Microcytic ... " • Iron deficiency ... Megaloblastic: Vitamin B12 ... morphologic #mcv #differential
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
E - Haemolytic anaemia ... paraesthesiae • Folate - Anaemia ... - Anaemia, neurological ... #diagnosis #signs ... #symptoms #nutrition
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology Microcytic ... deficiency anemia ... Sideroblastic anemia ... RBC: Vitamin B12 ... deficiency anemia
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Loss (without anaemia ... AI gastritis, Bariatric ... #Deficiency #differential ... diagnosis #causes #nutrition
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Risk Factors and Signs ... bowel resection/bariatric ... , Malnutrition Signs ... Haematological: Anaemia ... #riskfactors #symptoms
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
autoantibodies (pernicious anemia ... anemia, yellow ... wt loss • If anemia ... conditions, surgeries (bariatric ... - CBC, PBS - anemia
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
suspected: • Signs ... and symptoms of ... celiac disease • Iron-deficiency ... anemia unresponsive ... microscopic colitis Differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... anemia DDX: ... • Aplastic Anemia ... Megaloblastic Anemia ... Myelophthisic Anemia
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