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Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... fever, Urticaria, Allergic ... Immunological Target: Antigen-Ab ... #Allergic #Reactions
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
causes development ... Allergic reaction ... Macrophage engulfs antigen ... -> Antigen presentation ... cells recognize antigen
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... lgE causes mast-cell ... Hay fever, Food allergies ... , Drug allergies ... reactions #types #allergy
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Allergen-specific ... When the specific allergen ... hay fever, food allergies ... , and drug allergies ... Pathophysiology #Allergy
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
cell surfaces causes ... reaction against the antigen ... cell surface, and antigen-surface ... small antibody-antigen ... causes development
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... -> Antigen Exposure ... class II) process antigen ... Tissue edema #Allergic
Eosinophils (Eos) and hypereosinophilia (HE) Caused by eosinophilopoietic cytokines Common causes: - Drug reaction - Helminth infection -
hypereosinophilia (HE) Caused ... cytokines Common causes ... infection - Allergic ... disease Rare causes ... + T cells) - Allergic
Angioedema - Classification Diagnosis and Treatment Types of Angioedema: • Acute allergic angioedema - Usually occurs with
Angioedema: • Acute allergic ... exposure • Non-allergic ... cell-mediated in > 90% of cases ... or avoiding the allergen ... Treatment #management #allergy
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... Glucocorticoids Pugs (Allergies ... ): - Allergic ... Rhinitis - Allergic ... Differential #Diagnosis #Causes
Asthma: immunopathogenesis. Allergens attach to, and are taken up by, dendritic cells that he the respiratory
interaction of the allergen ... (antigen), antigen ... mucus production allergic
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