13 results
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... Overwhelming clinical syndrome ... rapidly, and empiric antibiotic ... #management #treatment ... #hematology
Oral Antibiotics for Acne - Indicated for Moderate-to-Severe Acne 
First-Line Drug Class: Tetracyclines 

In the last
Acne First-Line Drug ... reviewed mild acne treatment ... specifically for acne treatment ... #Pharmacology # ... Management #Dermatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... immune deficiency, Drugs ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Neurological Side Effects of Antipsychotic Drugs
Acute dystonia - Spasm of muscles of tongue, face, neck, back
Antiparkinsonian agents are diagnostic ... tremor ("rabbit syndrome ... months or years of treatment ... #SideEffects #pharmacology ... #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
A subset of hemophagocytic ... ) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
fatal • Causes: Drugs ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... #Hyperthermia #comparison ... #diagnosis #management
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
- Cytotoxic drugs ... - β-lactam antibiotics ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Criteria for Diagnosis ... disease: symptomatic treatment ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis ... #management
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
• A clinical diagnosis ... and lower jaw Treatment ... with acne: antibiotics ... diagnosis #management ... #Dermatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
life-threatening • Treatment ... Usual therapeutic management ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management