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diagnosis management hematology hlh lymphohistiocytosis anemia aplastic cns encephalitis infections inflammatory iris meningitis neurology oncology reconstitution rheumatology summary syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... that disrupts immune ... accumulation of clinical ... Infections+++: Virus ... CMV, HHV8,...), Bacteria
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... : Overwhelming clinical ... underlying genetic immune ... rapidly, and empiric antibiotic ... #hematology
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
Meningitis - Differential ... • Common clinical ... stain: Previous antibiotics ... Develops in the immune ... CNS #Infections #differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
mutations) • Immune ... Aplastic Anemia Clinical ... - β-lactam antibiotics ... HCV - HIV • Immune ... aplastic anemia Treatment
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
drug-resistant infection, bacterial ... noncompliance • Clinical ... initiation Clinical ... Leishmaniasis Differential ... Inflammatory #Syndrome #Differential
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