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leukemia chronic lymphocytic monoclonal classification cvid gammopathies globulin hemeonc hodgkins immunodeficiency immunology lymphoma mds mgus multiplemyeloma myelodysplasia myelodysplastic paraproteinemias polychondritis
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... Look for gamma gap ... diseases, CML, ... plasmacytoma, POEMs syndrome ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... autoimmune hemolytic anemia ... DDX - Other causes ... #immunology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... Agranulocytosis • Hypogammaglobulinemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Infection due to hypogammaglobulinemia ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... gastric tumors • Hematology ... anemia • Other ... Comment on type ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
(NSHL) - (most common ... Immunohistochemical studies (to differentiate ... number of sites of disease ... classification #hematology ... #oncology #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Nodosa: • PAN most commonly ... • Coronary arteries ... often causes arthritis ... Thrombosis and arterial ... #Diagnosis #Rheumatology
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