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management differential ana antinuclear classification fungal infections infectiousdiseases mycoses myelitis neurology patterns polychondritis relapsing transverse vasculitides vasculitis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... likely it will be clinically ... , Sjögren Syndrome ... , Interstitial Pulmonary ... #diagnosis #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Syndrome Diagnosis ... salivary ducts Clinical ... Arthritis Malignancy ... #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... , particularly scleritis ... purpura: strong sign ... C-ANCA) pattern: antibodies ... #rheumatology #
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Transverse Myelitis - Clinical ... • Bilateral signs ... and/or symptoms ... Antiamphiphysin antibodies
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
keratitis, uveitis, scleritis ... Most common • Sjogren ... Anti-Matrilin-1 Ab ○ Antibodies ... affected tissue Treatment ... Polychondritis #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... • Sclerosing mediastinitis ... has five major clinical ... Aspergillosis Pathophysiology ... Meningitis, septic arthritis
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