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diagnosis hematology rheumatology causes erythematosus hemolytic management sle systemic abscess activation agglutinin autoantibodies compared comparison disease erythemas extravascular hemolysis intravascular
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Clinical Presentation ... presentation) • Cutaneous ... • Symptoms of anemia ... younger pts) Differential ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... Extravascular #Causes #differential ... #anemia
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... - Hemolytic anemia ... (aPL) 30-45% Differential ... , Cutaneous mimickers ... Other auto-immune, Infectious
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... fibromyalgia) • Infections ... lymphoproliferative syndrome Clinical ... lymphopenia, low PLT • Anemia
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
(cutaneous or systemic ... Rash is usually ... Erythemas #comparison #table ... #differential # ... diagnosis #dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... (-) hemolytic anemia ... due to cold IgG ... • Lupus anticoagulant ... #Monoclonal #Differential
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... Lung Abscess - Clinical ... Leukocytosis, anemia ... Coli - P. ... Lung Abscess Differential
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... Petechial or purpuric rash ... SJIA], systemic lupus ... SLE], AOSD) • Infection ... with leukopenia, anemia
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