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Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
- Differential ... of breath • Neurologic ... Superior Vena Cava ... coma SIADH: • Hyponatremia ... #differential #
Causes of Secondary / Provoked Seizures - Differential Diagnosis Algorithm
Febrile
Infection
 • Sepsis
 • Encephalitis
 • Meningitis
Metabolic
Causes of Secondary ... Hyperglycemia • Hypocalcemia ... • Hyponatremia ... Degenerative • Dementia ... Provoked #Seizures #Neurology
Hyponatremia Diagnosis Algorithm
UOsm ≥ POsm - Vasopressin-Dependent
 • UNa < 20 mEq/L - Appropriate (↓ EABV)
EABV) - Consider: Hypovolemia ... Primary polydipsia, Low ... #diagnosis #differential ... #algorithm #causes ... #nephrology
Renal Replacement Therapy (RRT) - ICU One Pager Summary
Indications (AIEOU):
 • A: Acidosis (usually severe metabolic)
derangements (hyperkalemia ... Dialyzer is rigid case ... a non-tunneled CVC ... SLEDD (Sustained low ... #managment #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
time you have a case ... can be high or low ... Present (Uosm ≥100): Hypovolemia ... #differential # ... table #sodium #nephrology
Hyponatremia - Differential Algorithm
Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP
Hypotonic Hyponatremia: 
 • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
Hyponatremia - Differential ... : • Hypovolemia ... Algorithm #diagnosis #causes ... #nephrology #sodium ... #low
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
Anticoagulation Toxicity Hypernatremia ... is removed via CKRT ... circulation → ↓Mg Hypocalcemia ... dysfunction or low ... Toxicity #toxicology #nephrology
Hyponatremia Differential Diagnosis Algorithm in Cancer
UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Hyponatremia Differential ... appropriate • Hypovolemia ... chemotherapy, nausea ... #Differential # ... #oncology