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diagnosis hematology anemia hemolytic blood reactions algorithm causes classification cold disease extravascular hodgkins intravascular lymphoma neurology neurosarcoidosis oncology testing thromboticthrombocytopenicpurpura
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... younger pts) Differential ... #disease #hemolytic ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... ) (e.g. lupus, CLL ... . primary cold agglutin ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Agglutination - Cold agglutinins ... #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... hemorrhage and hemolysis ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Special Blood Product ... Can lead to sepsis ... Transfusions #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood products contain ... of transfused products ... Can lead to sepsis ... Transfusion #diagnosis #management ... #hematology #reactions
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... genes and gene products ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... #oncology #management
Neurosarcoidosis - Diagnosis and Treatment • 5 to 40% of sarcoidosis, Heterogeneous, often inaugural • Central
System (85%): Aseptic ... Cranial nerves (ll ... , Exclusion of Differential ... Diagnosis #Treatment #management ... #neurology #rheumatology
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