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diagnosis differential algorithm causes oncology pancytopenia afib alkaline alp anticoagulation aplastic b1 bleed chads2vasc classification encephalopathy folate folicacid hasbled hyophosphatasia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined ... Algorithm #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80-100 fL) • Bleeding ... (>100 fL) • B12 ... Deficiency • ... Folate Deficiency ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency Wernicke's encephalopathy is a neurological condition due to longstanding
of confusion, ataxia ... (broad-based gait ... and retrograde amnesia ... #vitaminB1 #B1 # ... Syndrome #diagnosis #comparison
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation C Congestive Heart Failure 1 H Hypertension 1 A2 Age >75 2 D Diabetes Mellitus 1 S2 Stroke,
S Stroke 1 B Bleeding ... history/anemia ... drinks/week) 1 #CHADS2 ... CHADS2VASc #HASBLED #Comparison ... AFib #Diagnosis #Hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... have hemolytic anemia ... interfered with leading ... differential #diagnosis #hematology ... #nutrition
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
deficiency. ... pump blockers is leading ... autoantibodies (pernicious anemia ... differential #diagnosis #hematology ... #nutrition
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... , GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... #oncology #hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• Vitamin C deficiency ... • Pernicious anemia ... /B12 deficiency ... ) - Waddling gait ... Hyophosphatasia #hepatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Platelet Disorders • Nutritional ... : vitamin B12 or ... folic acid deficiency ... treatments • Copper deficiency ... Syndromes #diagnosis #hematology
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