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diagnosis management differential cirrhosis product transfusion algorithm alkaline alkphos alp artificial astalt basophilia basophils biliary chemistry cholangitis coagulation comparison congenital
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... Phosphatase and Bilirubin ... mitochondria (mAST ... initial insult Bilirubin ... #Hepatology #Pathophysiology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
AIHA, Transfusion reactions ... Defects, Drugs, Liver ... - Peripheral Blood ... - Unconjugated Bilirubin ... Differential #Diagnosis #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... function similarly to mast ... during an allergic reaction ... Or Inflammatory Reactions ... #hematology #basophils
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... week • Direct bilirubin ... Elevation: • Bilirubin ... intestines, white blood ... diagnosis #algorithm #hepatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
- Transfusion Reactions ... of high parity blood ... donor • Pathophysiology ... without other cause ... #hematology #diagnosis
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
of hemolysis or liver ... associated with bilirubin ... and stress may cause ... in the blood ... #hepatology #diagnosis
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... eruptions, diarrhea, liver ... more likely to cause ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... eruptions, diarrhea, liver ... more likely to cause ... diagnosis #management #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... slightly elevated • Bilirubin ... or higher • Liver ... diagnosis #workup #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... DIC • Severe Liver ... Treat primary cause ... treatment #management #hematology
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