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diagnosis differential causes chronic management systemic workup acute b12 cll cobalamin cvid deficiency dermatology elevatedmcv erythematosus fatigue hemolytic hiv hypogammaglobulinemia
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Abnormality • SLE ... Iron deficiency anemia ... Systemic #Secondary #dermatology ... Differential #Diagnosis #Algorithm
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... Smear • Drugs Oval ... • Small Bowel Disorder ... • Liver Disease ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... ): SS, SC, SE, Sβ ... Consider RBC membrane disorder ... #workup #hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Arthritis • SLE ... Obstructive Pulmonary Disease ... • Somatization Disorder
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... folds • Painless oral ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... common • Antihistone
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Common Variable ... Immunodeficiency disorder ... • Infectious diarrhea ... autoimmune hemolytic anemia ... hypogammaglobulinemia #immunology #hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dysfunction, and/or disorders ... tongue), abd pain, diarrhea ... to IBD, celiac disease ... Treatment: • Oral
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... cells can indicate disease ... lymphoproliferative disorders ... • Neutropenia, anemia ... workup #oncology #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Nausea, vomiting, diarrhea ... infection - Most common ... : Oral and esophageal ... enzymes ↑ • Mild anemia ... • New onset SLE
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