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differential management pt prolonged abnormal aptt comparison table thrombocytopenia aflp algorithm bleeding blood bruising disorders hellp obstetrics pathophysiology platelet pregnancy
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/INR: ↑ • PTT: ... DIC • Severe Liver ... Treat primary cause ... #diagnosis #causes ... treatment #management #hematology
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
K Antagonists, Heparin ... to identify the cause ... #prolonged #diagnosis ... #hematology #evaluation ... mixing #studies #PTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... #Causes #diagnosis ... #differential #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
inhibitor • Liver ... Thromboplastin Time (PTT ... elevated in: • Heparin ... Thromboplastin #laboratory #hematology ... #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... #Causes #diagnosis ... #differential #hematology ... #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... - Differential Diagnosis ... Iatrogenic) • Liver ... #Algorithm #Causes ... #Hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Summary of Coagulation ... Medications - Heparin ... ) • Advanced Liver ... table #comparison #diagnosis ... #hematology #deficiency
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... deficiency • Liver ... #Differential #Diagnosis ... #hematology #rheumatology ... #nonpalpable #dermatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... : INR/PT, aPTT(liver ... bypass), LFT (liver ... #Differential #Diagnosis ... #hematology
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