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hepatology diagnosis lfts biliary primary transaminitis causes chemistry cholangitis elevated interpretation liver liverenzymes liverfunctiontests management rvalue treatment workup
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Tests - Differential ... Diagnosis Algorithm ... Ducts - PBC ... Congenital, Others, Cirrhosis ... LFTs #Elevated #Abnormal
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Diagnosis Algorithm ... disease US — Normal ... Bile Ducts • PSC ... Infiltrative • Cirrhosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary Cirrhosis ... cholestasis → Cirrhosis ... • ALP > 1.5 x ULN ... bile ducts Differential ... Primary #Biliary #Cirrhosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... - If both are normal ... hepatitis: < 1 • Cirrhosis ... chemistry #diagnosis #differential
Primary Biliary Cirrhosis - Management A. Initiate therapy - Initiate 1st line therapy with UDCA (13-15
Primary Biliary Cirrhosis ... if ALP > 1.5x ULN ... and/or abnormal ... care; routine calcium ... survey disease #PBC
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