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diagnosis hepatology differential algorithm transaminitis workup acute biliary calcium causes chemistry cirrhosis endocrinology gastroenterology hypercalcemia interpretation liver liverenzymes liverfunctiontests management
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Severe - ALT >15X ULN ... Mild - ALT < 5x ULN ... Burak @kwburak #LFTs ... #Elevated #Abnormal
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Severe ALT > 15x ULN ... Mild ALT < 5x ULN ... disease US — Normal ... • Others #LFTs
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
Hypercalcemia Evaluation ... likely - Mid range/ULN ... • If all normal ... endocrinology #calcium #elevated ... #evaluation #workup
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
or slightly elevated ... early on but elevated ... • ALP > 1.5 x ULN ... sclerosis group cholangitis ... Cirrhosis #PBC #cholangitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... specificity to elevated ... transaminitis #LFTs
Acute Pancreatitis - Diagnosis and Management - GrepMed Handbook Presentation: • Epigastric abdominal pain (90%, characteristically
2) Lipase > 3x ULN ... Lipase, Ca2+, LFTs ... Imaging: US (biliary evaluation ... diagnosis, can be normal ... (w/in 24h) if cholangitis
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