18 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... Renal disease - Bone ... #hepatology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... • XR, MRI to ... BrighamChiefs #Bone ... #diagnosis #causes ... #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... Most cases diagnosed ... : Inhibitor of bone ... formation causing poor bone ... Skeletal: - Bone
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Tumours - See Bone ... Pelvis - Positive Alkaline ... Gastrointestinal Disease • Bone ... Fractures #Pathologic #MSK ... #Orthopedics #Causes
Osgood-Schlatter Disease - MSK Radiology
Imaging Findings:
 • Infrapatellar fat-pad edema with loss of the patellar tendon
Osgood-Schlatter Disease - MSK ... fragmentation and mild bone ... tibial tuberosity Differential ... Schlatter #Disease #Knee ... #msk
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Causes of Knee Effusions ... - Differential ... Diagnosis Framework ... - Aneurysmal bone ... diagnosis #msk #
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Bisphosphonate suppresses bone ... damage weakens the bone ... Femur #Fractures #msk ... #differential # ... causes #pathophysiology
Focal Periphyseal Edema (FOPE lesion) - MSK Radiology
Imaging Findings:
 • Arrows identifying the characteristic edema-like signal
FOPE lesion) - MSK ... atraumatic adolescent knee ... physeal fusion and bone ... (save $$) Differential ... • Bone contusion
Bone Deformity / Limp - Differential Diagnosis Algorithm 
Infection
 • Septic Arthritis
 • Cortical Hypertrophy
 •
Bone Deformity / ... Limp - Differential ... Legg-Calve-Perthes Disease Knee ... • Dwarfism #Bone ... Deformity #Limp #MSK
Medial Meniscus Bucket Handle Tear - MSK Radiology
Imaging Findings:
 • Truncation of the medial meniscus on
Handle Tear - MSK ... Case description ... Differential diagnosis ... BucketHandle #Tear #knee ... #mri #clinical