11 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive ... three primary pathophysiologic ... causes differentiated ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
proteinuria, rapidly progressing ... tract, and often causes ... - Skin, glomeruli ... : - Kidneys: glomerular ... against MPO • Complement
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... infections are common causes ... of glomerular disease ... for ANCA-related vasculitis
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... inversely related to glomerular ... rate by tubulo-glomerular ... Differential #Diagnosis #Algorithm ... #Pathophysiology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... periumbilical region), nausea ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
proteinuria, Rapidly progressing ... • Kidneys: Non-glomerular ... is 50 years • Progressive ... immune GN (rapidly progressive ... tract, and often causes
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... #glomerular #disease
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... palpable purpura 2/2 vasculitis ... Goodpasture's cause ... Path: rapidly progressive ... hypercellular glomeruli
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
dysfunction PATHOPHYSIOLOGY ... inflammation -> progressive ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
: • 1400 new cases ... monophasic Pathophysiology ... IgG index • Progression ... • Infectious causes ... - Sjogren - Vasculitis