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diagnosis rheumatology differential large size small cryoglobulinemia cryoglobulins cutaneous ddxof dermatology erythematosus glomerulonephritis im lupus management progressive rapidly rheum rpgn
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... #Small #Medium ... #Vessel #Size #Classification ... #ANCA #Differential ... #Algorithm #Ddxof
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis: + MPO-ANCA ... MEDIUM VESSEL ... aortic aneurysm • Medium ... against MPO • Complement ... #rheumatology #classification
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
, medium vessel ... Medium vessel vasculitis ... large artery, medium ... basement membrane; ANCA ... #Large #Classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... (C-ANCA): GPA > ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis Involving ... Urticaria • Medium ... • ANCA Associated ... with IgG/IgM deposits ... elevatum diutinum Medium
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... Vasculitis Vasculitis ... of medium vessels ... small vessels - ANCA-associated ... dermatomyositis #Size #Classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... infiltration of IgG4 ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... • IgA vasculitis ... • Vasculitis ... diagnosis #types #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... vasculitis, rheumatoid ... • Mesenteric vasculitis ... RNP antibodies, Complement
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