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rheumatology vasculitis activation cryofibrinogenemia cryoglobulinemia dermatology extravascular hemolysis hemolytic hodgkins intravascular lymphoma macrophage mas nonpalpable oncology palpable types vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... • Autoimmune diseases ... (e.g. systemic lupus ... #classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... - Hemolytic anemia ... #Differential # ... Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
thrombocytopenic purpura ... usually IgG) (e.g. lupus ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Skin necrosis • Purpura ... thrombophlebitis, pulmonary ... • Negative causes ... Antiphospholipid syndrome ... hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... SLE) • Urinalysis ... Serologies for Cryoglobulins ... #diagnosis #rheumatology ... #classification
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... number of sites of disease ... Hodgkin Lymphoma Treatment ... #hematology #oncology ... #management
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