12 results
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Anemia • ... Malignancy Infectious ... • Endocarditis ... Arthritis • SLE ... Fatigue Syndrome
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... • Richter’s Syndrome ... • Sezary syndrome ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
DDX - Other causes ... : • Nephrotic syndrome ... syndrome, HIV) ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... • AnemiaAplastic ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #diagnosis #hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... tests in Behcet syndrome ... ) Differential Diagnosis ... adenopathy (PFAPA) syndrome ... #diagnosis #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... dermatomyositis, Sjogren syndrome ... • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... (NSHL) - (most common ... #diagnosis #classification ... #hematology #oncology ... #management
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Lady Windermere Syndrome ... : • Syndrome of ... Bone Marrow - Anemia ... #differential #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
changes (POEMS syndrome ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... Comment on type ... #diagnosis #hematology