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chronic hemolytic leukemia rheumatology agglutinin cll cold effusion erythematosus extravascular hemolysis hodgkins infections infectiousdiseases intravascular lupus lymphocytic mds monoclonal mycobacteria
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Diagnosis Algorithm ... • Anemia • ... #Fatigue #Differential ... #Diagnosis #Algorithm
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... e.g. lupus, CLL, lymphoma ... #differential # ... diagnosis #hematology ... #anemia
Causes of Pleural Effusion - Differential Diagnosis Algorithm Transudate - Hydrostatic • Congestive heart failure • Constrictive
Causes of Pleural ... Effusion - Differential ... Diagnosis Algorithm ... #Diagnosis #Algorithm ... #Hepatology #causes
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... include fatigue ... anemia • Cold ... younger pts) Differential ... #hematology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunohistochemical studies (to differentiate ... number of sites of disease ... #diagnosis #classification ... #hematology #oncology ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
sweats • Extreme fatigue ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... CML Symptoms: • Fatigue ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Clinical evidence of (fatigue ... Classification: ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... lymphopenia, low PLT • Anemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Symptoms: • Fatigue ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology ... #oncology
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