13 results
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... • Anemia • ... Arthritis • SLE ... Disease Neurologic ... #Fatigue #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... #differential # ... diagnosis #hematology ... #anemia
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Symptoms: • Fatigue ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome ... include fatigue ... anemiaCold ... younger pts) Differential ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... sweats • Extreme fatigue ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Symptoms: • Fatigue ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology ... #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Clinical evidence of (fatigue ... Classification: ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... lymphopenia, low PLT • Anemia
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... • Fevers • Fatigue ... vasculitis, and SLE ... #diagnosis #rheumatology ... #classification
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Hematologic malignancy ... Bone Marrow - Anemia ... 35 percent) • Fatigue ... NTM #Infections #differential