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differential oncology algorithm anemia behcet chronic cll cryofibrinogenemia erythematosus hemolytic hemophagocytic hlh hodgkins leukemia lupus lymphocytic lymphohistiocytosis lymphoma macrophage mas
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... ): SS, SC, SE, Sβ ... Agglutination - Cold ... #Algorithm #workup ... #hematology #testing
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... erythematosus [SLE ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Chronic B-cell activation ... #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
thrombophlebitis, pulmonary ... Cryofibrinogenemia Diagnosis ... Antiphospholipid syndrome ... #rheumatology # ... hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
matter, spinal cord ... Oral aphthae : SLE ... • Arthritis: SLE ... #diagnosis #management ... signs #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... age, however the disease ... #management #treatment ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... • Cogan Syndrome ... vasculitis, and SLE ... #rheumatology # ... classification
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... cells can indicate disease ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... : • 10%-15% Pulmonary ... Nephrogenic DI Hematologic ... #Rheumatology # ... Diagnosis #Management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Workup ... number of sites of disease ... #classification ... #hematology #oncology ... #management
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