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differential management infections infectiousdiseases syndrome vasculitis aids antibodies antinuclear antinxp2dm autoimmune classification common cvid dermatology hiv hypogammaglobulinemia immunodeficiency immunology lupus
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... likely it will be clinically ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... , dermatomyositis ... Induced Lupus: • Symptoms ... Chronic B-cell activation ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... [SLE], AOSD) • ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
papules Clinical ... had more severe disease ... : • ILD was diagnosed ... #AntiNXP2 #Dermatomyositis ... #rheumatology #
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
MAC pulmonary disease ... Hematologic malignancy ... Disease: Clinical ... • Clinical (Symptoms ... Imaging, high res CT
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
years Clinical ... Granulomatous lymphocytic interstitial ... lung disease (GLILD ... Chest CT: • Ground-glass ... hypogammaglobulinemia #immunology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammatory lesions-interstitial ... lupus erythematosus ... Presentation - Systemic Symptoms ... SLE) • Urinalysis ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... : • 10%-15% Pulmonary ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
• CT: Halo sign ... papules, pustules, erythematous ... Constitutional symptoms ... fever, rales, interstitial ... Infections #HIV #AIDS #pulmonary
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... lung disease Malignancy ... lung disease • ... lung disease • ... Myositis #Myopathy #rheumatology
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