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differential management syndrome vasculitis antibodies antinuclear classification common cryofibrinogenemia hypogammaglobulinemia immunodeficiency immunology lupus macrophage mas myopathy myositis patterns scleroderma sclerosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... (SLE), Systemic ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary ... #patterns #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... , dermatomyositis ... rheumatologic diseases ... Chronic B-cell activation ... #Diagnosis #Rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... : ILD (interstitial ... lung disease), ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... lung disease (GLILD ... Chest CT: • Ground-glass ... anemia) • Systemic ... hypogammaglobulinemia #immunology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... [SLE], AOSD) • ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammatory lesions-interstitial ... erythematosus, ... Symptoms (Sx) in ... SLE) • Urinalysis ... #rheumatology #
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... associated with autoimmune ... processes: • Systemic ... #rheumatology # ... hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
lung disease Malignancy ... lung disease • ... lung disease • ... • Conduction system ... Myositis #Myopathy #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
as SLE, atherosclerotic ... Symptoms (SX) in ... ischemia • Skin: Erythematous ... inflammatory lesions - interstitial ... #Rheumatology
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