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management vasculitis antibodies antinuclear cardiology classification cvid endocarditis hypogammaglobulinemia immunodeficiency immunology lupus patterns polycythemia sjogrens syndrome variable vasculitides workup
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... (SLE), Systemic ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... rheumatologic diseases ... Kidney disease common ... #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... phenomenon (16%) MSK ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... lung disease (GLILD ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... Diagnosis: Systemic ... discrepancies Findings ... SLE) • Urinalysis ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... , such as SLE, atherosclerotic ... Nodosa: • PAN most commonly ... often causes arthritis ... #Diagnosis #Rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Diagnosis Algorithm ... frequently affected systems ... Better call hematology ... #Diagnosis #Algorithm ... #workup #hematology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Differential Diagnosis ... , verrucous) - Lung ... regurgitation • Autoimmune ... (SLE Libman Sacks ... #Diagnosis #cardiology
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