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activation classification fungal igg4 infections lupus macrophage mas mycoses patterns phenotypes related sjogrens systemic vasculitides vasculitis workup
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... , Interstitial Pulmonary ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... alopecia Differential ... Diagnosis: • ANCA-associated ... syndrome Arthritis ... #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... MALT Lymphoma • Lung ... #Rheumatology # ... Diagnosis #Management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Clinical history ... biliary, renal, lung ... concentration PET-CT ... #diagnosis #management ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... inflammatory lesions-interstitial ... ) pattern: antibodies ... SLE) • Urinalysis ... #diagnosis #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... has five major clinical ... Meningitis, septic arthritis ... ) #Mycoses #InfectiousDiseases ... #Management #Infections
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