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differential classification infectiousdiseases oncology activation antinuclear antinxp2 antinxp2dm cardiology chronic cll cryofibrinogenemia dermatomyositis erythematosus fungal hemeonc hodgkins hypogammaglobulinemia immunodeficiency immunology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... lung disease (GLILD ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... likely it will be clinically ... Lymphoproliferative Disorders, Infection ... , Interstitial Pulmonary ... #rheumatology #diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... MALT Lymphoma • Lung ... #Rheumatology # ... Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
rheumatologic diseases ... fibromyalgia) • Infections ... • Libman-Sacks endocarditis ... Kidney disease common ... #Rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... Complications: 1) Infection ... 3) Monoclonal antibodies ... Leukemia #oncology #hematology ... #management
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ... EGPA) • Auto-antibodies ... confirm DAH, r/o infection ... sparing of the lung ... #management #treatment
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Tenderness → Consider infectious ... lung disease Malignancy ... lung disease • ... lung disease • ... Myositis #Myopathy #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
associated with autoimmune ... Malignancy • Infections ... Antiphospholipid syndrome ... #rheumatology # ... hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... erythematosus [SLE ... ], AOSD) • Infection ... #Diagnosis #Management ... #Hematology #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... LFT • ESR • ANA ... ) pattern: antibodies ... SLE) • Urinalysis ... #rheumatology #
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