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activetb latenttb tb common differential hemophagocytic hlh hypogammaglobulinemia immunodeficiency immunology infectiousdiseases lymphohistiocytosis mas mycobacteria nontuberculous ntm polychondritis relapsing sjogrens summary
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
abscess Primary ... • HIV: 2/3 pulmonary ... characteristic features Clinical ... #TB #Diagnosis ... #Management #Treatment
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
abscess Primary ... • HIV: 2/3 pulmonary ... characteristic features Clinical ... #TB #Diagnosis ... #Management #Treatment
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... lung disease (GLILD ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... erythematosus [SLE ... #Activation #Syndrome ... #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
of macrophages ... production of pro-inflammatory ... : SLE+++, Adult-onset ... #management #treatment ... #summary #rheumatology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Hematologic malignancy ... Disease: Clinical ... Lung Disease: ... Imaging, high res CT
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... MALT Lymphoma • Lung ... #Rheumatology # ... Diagnosis #Management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
as: • SLE • RA ... ○ Tuberculosis ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
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