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differential activetb hematology tb cns common cvid fungal hypogammaglobulinemia immunodeficiency immunology macrophage mycobacteria mycoses neurology nontuberculous ntm opportunistic sjogrens variable
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
of a latent infection ... • HIV: 2/3 pulmonary ... characteristic features Clinical ... Diagnosis: Latent ... #Management #Treatment
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
of a latent infection ... • HIV: 2/3 pulmonary ... characteristic features Clinical ... Diagnosis: Latent ... #Management #Treatment
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
MAC pulmonary disease ... Disease: Clinical ... Lung Disease: ... Imaging, high res CT ... #infectiousdiseases
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
years Clinical ... lung disease (GLILD ... Chest CT: • Ground-glass ... , HIV) • Glucocorticoid ... #diagnosis #management
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... • CT: Halo sign ... #Infections #HIV ... #AIDS #pulmonary ... #infectiousdiseases
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
HIV / AIDS - Differential ... of latent pathogens ... should be based on clinical ... Antimicrobial treatment ... enhancement on CT
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Syndrome (MAS) ... erythematosus [SLE ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... MALT Lymphoma • Lung ... #Rheumatology # ... Diagnosis #Management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... five major clinical ... yeast • At risk: AIDS ... ) #Mycoses #InfectiousDiseases ... #Management #Infections
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