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differential hematology aids antinxp2 antinxp2dm autoimmune cvid dermatology dermatomyositis hiv hypogammaglobulinemia immunodeficiency immunology infections infectiousdiseases lupus myopathy myositis variable vasculitis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Syndrome (MAS) ... #Macrophage #Activation ... #Syndrome #Diagnosis ... #Management #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... Kidney disease common ... Chronic B-cell activation ... #Diagnosis #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
years Clinical ... lung disease (GLILD ... Chest CT: • Ground-glass ... hemolytic anemia) • Systemic ... #diagnosis #management
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
• CT: Halo sign ... papules, pustules, erythematous ... function of alveolar macrophages ... fever, rales, interstitial ... Infections #HIV #AIDS #pulmonary
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
as SLE, atherosclerotic ... purpura: Strong sign ... Nodosa: • PAN most commonly ... ischemia • Skin: Erythematous ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... lung disease Malignancy ... lung disease • ... lung disease • ... • Conduction system
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
papules Clinical ... had more severe disease ... • Myoglobin Association ... was diagnosed in ... #management #rheumatology
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