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differential classification antibodies antinuclear autoimmune cryoglobulins lupus management myositis nephrology patterns renal sjogrens types vasculitides
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... vasculitis, Behcet ... disease, Cryoglobulinemia ... testing: anti-ANCA ... , anti-GBM ab, ANA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Behçet Syndrome ... inflammatory lesions-interstitial ... purpura: strong sign ... , and SLE) • Urinalysis ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... (SLE), Systemic ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary ... #patterns #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... : • ANCA-associated ... syndrome Arthritis ... antibodies • (-) ANA ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... syndrome) #Cryoglobulinemia
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... , such as SLE, atherosclerotic ... purpura: Strong sign ... • Behcet syndrome ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... 7%, Cryoglobulinemia ... MALT Lymphoma • Lung ... #Rheumatology #
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
• Anti-NXP2 (ANA ... lung disease Malignancy ... lung disease • ... or head drop • ANA ... lung disease •
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